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药物结合作用的机制及这些反应在外源物的失活和排除方面的重要功能现虽已有深入了解,结合与脱结合反应在药物毒性中的作用则没有受到广泛的重视。某些药物结合物作为毒性中介物可导致细胞损伤。化学致癌作用的早期研究指出N-羟基乙酰氨基芴的硫酸酯是一种高活性的亲电物,可攻击亲核的组织成分。在染料工厂接触2-萘胺的工人中膀胱癌的诱发似乎包括2-萘胺在肝脏中的氧化及与葡糖
The mechanism of drug binding and the important functions of these reactions in the inactivation and elimination of exogenous substances are now well understood. The role of binding and debinding reactions in drug toxicity has not received widespread attention. Certain drug conjugates act as toxic mediators that can cause cell damage. Early studies of chemical carcinogenesis have indicated that the sulfate ester of N-hydroxyacetamidoxime is a highly active electrophile that can attack nucleophilic tissue components. Induction of bladder cancer in workers exposed to 2-naphthylamine in dye factories seems to involve oxidation of 2-naphthylamine in the liver and with glucose