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经ＩＬ－２基因转移瘤苗治疗后荷瘤小鼠肺转移结节明显减少、存活期明显延长，与ＩＬ－１或低剂量Ｃｙ合用后，可使荷瘤小鼠的肺转移结节更少，存活期更长，特别是当ＩＬ－２基因转移的瘤苗、ＩＬ－１、低剂量Ｃｙ三者合用时抗肿瘤转移效果最强。对瘤苗治疗后荷瘤小鼠体内免疫功能的研究表明，小鼠脾脏ＣＴＬ活性、ＮＫ活性、ＩＬ－２导的ＬＡＫ活性均显著增强，脾脏细胞分泌ＩＬ－２和ＴＮＦ水平也显著升高，当与ＩＬ－１、低剂量Ｃｙ合用时，上述抗肿瘤免疫功能升高得更加明显，可见ＩＬ－２基因转移的瘤苗能通过有效地激活体内抗肿瘤免疫功能而具有显著的抗肿瘤转移效果，将其与ＩＬ－１或低剂量Ｃｙ联合应用时抗肿瘤效果更佳，当三者同时合用时抗肿瘤效果最佳。
The metastasis of lung metastases in tumor-bearing mice was significantly reduced and survival was significantly prolonged after IL-2 gene transfer tumor vaccine treatment. Combined with IL-1 or low-dose Cy, tumor-bearing mice can have fewer metastatic lung nodules. Survival is longer, especially when the IL-2 gene transfer tumor vaccine, IL-1, and low-dose Cy are combined, the anti-tumor metastasis effect is the strongest. The study of immune function in tumor-bearing mice after treatment with tumor vaccines showed that the CTL activity, NK activity, IL-2-induced LAK activity in the spleen of mice were significantly enhanced, and the levels of IL-2 and TNF secreted by spleen cells were also significantly increased. When combined with IL-1 and low-dose Cy, the above-mentioned anti-tumor immune function increased more significantly. It can be seen that the tumor vaccine of IL-2 gene transfer can have a significant anti-tumor metastasis effect by effectively activating antitumor immune function in vivo. The anti-tumor effect is better when it is combined with IL-1 or low-dose Cy, and when the three are combined at the same time, the anti-tumor effect is the best.