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目的:探讨血清降钙素原(PCT)和C反应蛋白(CRP)联合检测在感染性疾病诊断中的应用。方法:将收治的160例感染性疾病患者分为细菌感染组95例和非细菌感染组65例,另选同期健康体检者50例作为对照组。分别检测各组研究对象血清中PCT和CRP。结果:与非细菌感染组和健康对照组比较,细菌感染组患者血清平均PCT和CRP水平和阳性率均显著升高(P<0.05);细菌感染组患者在感染得到控制后,其血清PCT和CRP水平迅速回落至正常水平。结论:血清PCT、CRP可用于感染性疾病的诊断和鉴别诊断,动态监测血清PCT和CRP水平,可及时了解患者的病情变化,为提高疗效及调整抗菌药物应用提供依据。
Objective: To investigate the combination of serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of infectious diseases. Methods: A total of 160 cases of infectious diseases were divided into 95 cases of bacterial infection and 65 cases of non-bacterial infection. Another 50 cases of healthy subjects were selected as control group. The serum PCT and CRP in each group were detected. Results: Compared with non-bacterial infection group and healthy control group, the serum PCT and CRP levels and the positive rate in bacterial infection group were significantly increased (P <0.05). After the infection was controlled, the serum PCT and CRP levels quickly dropped back to normal levels. Conclusions: Serum PCT and CRP can be used in the diagnosis and differential diagnosis of infectious diseases. Dynamic monitoring of serum PCT and CRP level can be used to understand the changes of patients’ condition and provide basis for improving curative effect and adjusting the application of antimicrobial agents.