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目的:探讨清肺消积汤联合化疗对晚期肺鳞癌的生活质量(Karnofsky)评分和CYFRA21-1的影响。方法:将120例晚期肺鳞癌患者随机分为治疗组(清肺消积汤+化疗组)和对照组(化疗组)。对照组应用紫杉醇/吉西他滨+顺铂联合化疗,21 d为1个周期,2个周期为1个疗程。治疗组同时加用清肺消积汤,每日1剂,42 d为1个疗程。结果:Karnofsky评分治疗组改善率为57.4%(39/68),对照组改善率为38.5%(20/52),两组在统计学上有显著差异性(P<0.05)。治疗组治疗前后CYFRA2-11的数值为(16.23±13.55),(3.45±3.32)μg.L-1,前后对比差异有显著性(P<0.01)。对照组治疗前后CYFRA2-11的数值为(16.98±12.35),(13.11±10.45)μg.L-1,前后对比差异无显著性。结论:清肺消积汤联合化疗对晚期肺鳞癌能改善生活质量,降低CYFRA21-1水平。
Objective: To investigate the effect of Qingfei Xiaoji Decoction combined with chemotherapy on the quality of life (Karnofsky) score and CYFRA21-1 in advanced squamous cell carcinoma of lung. Methods: One hundred and twenty patients with advanced squamous cell carcinoma of lung were randomly divided into treatment group (Qingfei Xiaoji Tang + chemotherapy group) and control group (chemotherapy group). The control group with paclitaxel / gemcitabine + cisplatin combined with chemotherapy, 21 d for a cycle, 2 cycles for a course of treatment. The treatment group also added Qingfei Xiaoji Tang, 1 day, 42d for a course of treatment. Results: The improvement rate of Karnofsky score was 57.4% (39/68) in the treatment group and 38.5% (20/52) in the control group, with statistically significant difference (P <0.05). The values of CYFRA2-11 in the treatment group before and after treatment were (16.23 ± 13.55) and (3.45 ± 3.32) μg.L-1, respectively, with significant differences between before and after treatment (P <0.01). The values of CYFRA2-11 before and after treatment in the control group were (16.98 ± 12.35) and (13.11 ± 10.45) μg.L-1, respectively, with no significant difference between before and after treatment. Conclusion: Qingfei Xiaoji Decoction combined with chemotherapy for advanced lung squamous cell carcinoma can improve the quality of life and reduce the level of CYFRA21-1.