肾病综合征是以大量蛋白尿、低蛋白血症、高脂血症及高度水肿为特征的临床综合征，常伴有高凝状态及血栓形成，由于肾小球内瘀血在肾小球损伤中起着重要作用，因此抗凝治疗亦日益受到重视。既往普遍应用普通肝素（UFH）抗凝治疗，但易造成出血，并可导致伴有血栓形成的血小板减 Nephrotic syndrome is a clinical syndrome characterized by a large amount of proteinuria, hypoproteinemia, hyperlipidemia and highly edema, often accompanied by hypercoagulable state and thrombosis, due to glomerular blood stasis in the glomerular injury Plays an important role, so anticoagulant therapy is also increasingly valued. Unfractionated heparin (UFH) anticoagulation was commonly used in the past, but bleeding was easily caused and thrombocytopenia associated with thrombosis