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肺癌为恶性肿瘤死亡之首，70％以上患者在确诊时已丧失手术机会，以化疗为主的综合治疗，占重要地位。多药耐药（Multidrug Resistance MDR）是化疗失败的主要原因之一。肺癌的耐药机理复杂，目前已知与多药耐药基因（Multidrug Resistance－1MDR1）、多药耐药相关蛋白（Mu
Lung cancer is the leading cause of death from malignant tumors. More than 70% of patients have lost surgical opportunities when they are diagnosed, and chemotherapy-based comprehensive treatment plays an important role. Multidrug resistance (MDR) is one of the major causes of chemotherapy failure. The mechanism of drug resistance in lung cancer is complex and is currently known as Multidrug Resistance-1 (MDR1) and multidrug resistance-associated protein (Mu).