论文部分内容阅读
目的探讨程序性细胞凋亡因子4(PDCD4)和生存素(survivin)在尖锐湿疣(CA)、鲍恩样丘疹病(BP)、Bow en病(BD)、鳞状细胞癌(SCC)皮损中的表达及临床意义。方法采用免疫组化M ax Vision方法检测CA组30例、BP组28例、BD组10例、SCC组11例皮损和正常对照组10例中PDCD4及survivin的表达。结果 1BP组、BD组和SSC组皮损中PDCD4表达均较正常对照组低(P<0.05),SCC组较CA组表达低(P<0.05),其余各组间比较差异无统计学意义(P>0.05);2survivin在BD组和SCC组的表达高于正常对照组,SCC组高于CA组,差异均有统计学意义(P<0.05),其余各组间差异无统计学意义(P>0.05)。结论 PDCD4有抑制细胞异常增殖的作用,在皮肤良性增殖性疾病向恶性皮肤肿瘤的转化中发挥一定抑制作用;survivin过度表达可抑制细胞凋亡、促进细胞增殖。
Objective To investigate the relationship between the expression of PDCD4 and survivin in condyloma acuminatum (CA), Bowenoid papulosis (BP), Bowen’s disease (BD) and squamous cell carcinoma (SCC) In the expression and clinical significance. Methods Immunohistochemical M ax Vision method was used to detect the expression of PDCD4 and survivin in 30 cases of CA group, 28 cases of BP group, 10 cases of BD group, 11 cases of SCC group and 10 cases of normal control group. Results The expression of PDCD4 in skin lesions of 1BP, BD and SSC groups was lower than that of normal control group (P <0.05), while the expression of PDCD4 in SCC group was lower than that of CA group (P <0.05). There was no significant difference between the other groups P> 0.05). The expression of 2survivin in BD and SCC groups was higher than that in normal control group, and SCC group was higher than that in CA group (P <0.05). There was no significant difference between other groups > 0.05). Conclusion PDCD4 can inhibit the abnormal proliferation of cells and play an inhibitory role in the transformation of benign and malignant skin tumors into malignant tumors. Survivin overexpression can inhibit apoptosis and promote cell proliferation.