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目的评价米诺环素辅助治疗慢性牙周炎临床疗效及安全性。方法入选62例慢性牙周炎患者,随机分为试验组30例和对照组32例。对照组用刮治、洁治以及根面的平整与修复,试验组在对照组基础上加用米诺环素,每周治疗1次,连续4周。3个月后,比较2组患者菌斑指数(PLI)、牙龈指数(GI)、探诊深度(PD)及附着丧失(AL)。结果 3个月后,试验组与对照组较治疗前菌斑指数、牙龈指数、探诊深度及附着丧失均明显降低(P<0.05),但试验组探诊深度及附着丧失指标显著低于对照组(P<0.05)。试验组出现4例患者一过性疼痛及刺激症状。结论米诺环素辅助治疗慢性牙周炎较单独应用机械治疗临床疗效好。
Objective To evaluate the clinical efficacy and safety of minocycline in the treatment of chronic periodontitis. Methods Sixty-two chronic periodontitis patients were randomly divided into experimental group (n = 30) and control group (n = 32). The control group with scraping, cleaning and root formation and repair, the experimental group in the control group based on the use of minocycline, once a week for 4 weeks. Three months later, plaque index (PLI), gingival index (GI), probing depth (PD) and attachment loss (AL) were compared between the two groups. Results After 3 months, the plaque index, gingival index, probing depth and attachment loss of experimental group and control group were significantly lower than those of control group (P <0.05), but the depth of exploration and attachment loss in test group and control group were significantly lower than those in control group Group (P <0.05). Four patients in the test group had transient pain and irritation. Conclusions Minocycline adjuvant treatment of chronic periodontitis is more effective than mechanical treatment alone.