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特异性自身抗体与皮肤狼疮相关的有力证据可见于NLE和SCLE。已有实验表明:抗Ro/SS/-A抗体可与培养的角朊细胞表面结合。本文针对以下问题设计动物模型研究皮肤狼疮的抗体结合。1.抗Ro/SS-A抗体在体内是否结合到皮肤;2.抗Ro/SS-A抗体的结合是否对Ro/SS-A抗原具特异性;
Strong evidence of specific autoantibodies associated with cutaneous lupus can be found in NLE and SCLE. It has been experimentally shown that the anti-Ro / SS / -A antibody binds to the surface of cultured keratinocytes. In this paper, the following questions were designed to study animal models of skin lupus antibody binding. 1. Whether the anti-Ro / SS-A antibody binds to the skin in vivo; 2. Whether the binding of the anti-Ro / SS-A antibody is specific to the Ro / SS-A antigen;