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目的:探讨顺铂腹腔热灌注联合静脉化疗治疗中晚期腹盆腔恶性肿瘤的疗效。方法:经病理组织学或细胞学确诊的Ⅲ期或Ⅳ期患者110例(男63例,女47例)。顺铂50mg/m2加NS1500mL/m2加热至43℃快速注入腹膜腔,CF0.2g/m2静脉滴注第1天~第5天,5蛳Fu500mg/m2行锁骨下静脉穿刺置管应用可控微量泵持续静脉输注24h,第1天~第5天。4周期后评价疗效与毒副反应。结果:97例可评价患者中部分缓解(PR)31例,SD20例,总有效率31.9%(31/97)。结论:顺铂腹腔热灌注联合静脉化疗治疗中晚期腹盆腔恶性肿瘤有效且安全。
Objective: To investigate the efficacy of cisplatin intraperitoneal hyperthermic perfusion combined with intravenous chemotherapy in the treatment of advanced abdominal pelvic malignancies. Methods: 110 patients with stage Ⅲ or Ⅳ confirmed by histopathology or cytology (63 males and 47 females). Cisplatin 50mg / m2 plus NS1500mL / m2 heated to 43 ℃ rapid injection into the peritoneal cavity, CF0.2g / m2 intravenous drip 1 to 5 days, 5 Fu Fu 500mg / m2 line subclavian vein catheterization controllable trace Pump continuous intravenous infusion of 24h, 1 day to 5 days. After 4 cycles evaluation of efficacy and toxicity. Results: Of the 97 evaluable patients, 31 were partially relieved (PR) and 20 were SD. The total effective rate was 31.9% (31/97). Conclusion: Intraperitoneal hot perfusion of cisplatin combined with intravenous chemotherapy is effective and safe in the treatment of advanced abdominal pelvic malignancies.