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目的探讨小剂量米非司酮治疗子宫腺肌病的效果。方法41例确诊为子宫腺肌病的患者,口服米非司酮10mg/d,连用6个月。结果用药过程中均闭经。未出现明显的副作用。停药后随访1年,痛经程度用药后较用药前明显减低;月经异常明显改善;用药前子宫体积平均为(10.9×9.5×5.6)cm~3,用药后的子宫体积平均为(8.1×6.3×4.1)cm~3。P均<0.01,有统计学意义。其中36例治愈,3例复发后行手术治疗,2例>45岁患者致绝经。结论小剂量米非司酮治疗子宫腺肌病疗效显著,副作用小。
Objective To investigate the efficacy of low dose mifepristone in the treatment of adenomyosis. Methods 41 patients diagnosed as adenomyosis patients, oral mifepristone 10mg / d, once every 6 months. Results amenorrhea during the medication. No obvious side effects. The patients were followed up for 1 year after discontinuation of drug therapy. The degree of dysmenorrhea was significantly lower than that before treatment, and the abnormal menstruation was improved. The average uterine volume before medication was (10.9 × 9.5 × 5.6) cm ~ 3, and the average uterine volume after medication was (8.1 × 6.3 × 4.1) cm ~ 3. P <0.01, with statistical significance. Among them, 36 cases were cured, 3 cases were treated by surgery after recurrence, and 2 cases> 45 years old caused menopause. Conclusion Small doses of mifepristone treatment of adenomyosis significant effect, side effects.