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目的探讨细胞周期素E(CyclinE)在下咽癌组织中的表达及其与各临床病理因素的关系。方法采用免疫组化S-P法检测35例下咽癌组织和20例正常下咽黏膜组织中CyclinE的表达情况。结果 (1)CyclinE在下咽癌组织中的阳性表达率为62.9%,明显高于正常下咽黏膜(0)(P<0.05)。(2)CyclinE蛋白在下咽癌组织中的表达与淋巴结转移、临床分期、病理分级、肿瘤大小、吸烟量、年龄和性别无相关性(P>0.05)。结论 CyclinE蛋白的高表达可能促进下咽癌的发生,可以作为下咽癌早期诊断和靶向治疗的重要标志物。
Objective To investigate the expression of cyclin E in hypopharyngeal carcinoma and its relationship with clinicopathological factors. Methods Immunohistochemical S-P method was used to detect the expression of CyclinE in 35 cases of hypopharyngeal carcinoma and 20 cases of normal hypopharyngeal mucosa. Results (1) The positive expression rate of CyclinE in hypopharyngeal carcinoma was 62.9%, which was significantly higher than that of normal hypopharyngeal mucosa (0) (P<0.05). (2) The expression of CyclinE protein in hypopharyngeal carcinoma had no correlation with lymph node metastasis, clinical stage, pathological grade, tumor size, smoking, age and sex (P>0.05). Conclusion The high expression of CyclinE protein may promote the occurrence of hypopharyngeal carcinoma, and it can be used as an important marker for early diagnosis and targeted therapy of hypopharyngeal carcinoma.