Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of rats.Methods: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic L.macrophylla(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups.The urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional trials.Anti-urolithiatic effect of cystone was significantly(P<0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity test.Conclusions:The results of this study demonstrated very promising antiurolithiatic effect of L.macrophylla extract with preventive and therapeutic treatments in this experimental condition. Objective: To investigate the antilithiatic effect of the whole Leema macrophylla (L macrophylla) Roxb (Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of rats. Methods: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups Preventive group was further subdivided into 3 groups of 6 different molecules: preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM) Therapeutic lithiatic L macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75 % (v / v) ethylene glycol in the drinking water of all groups except the PC and TC groups. the urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ediylene glycol, which w Results: Significant difference on recovery was observed between preventive and dierapeutic interventional trials. Anti-urolithiatic effect of Cystone was significantly (P <0.001) higher than extracts. L macrophylla extract was found nontoxic in the acute toxicity test. Conclusions: The results of this study demonstrated very promising antiurolithiatic effect of L. macrophylla extract with preventive and therapeutic treatments in this protocol condition .