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目的评价外源性补充磷酸肌酸对PCI术后心肌损伤的影响。方法选择接受PCI的冠心病患者200例,随机分为试验组和对照组,每组各100例。对照组采用指南推荐的常规治疗方案,试验组在常规治疗的基础上,术后即刻给予磷酸肌酸钠静脉滴注,2次/d,2 g/次,连续应用3 d。所有患者PCI术前及术后3 d检测肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTnI)水平。结果试验组与对照组PCI术前CK-MB和cTnI差异无统计学意义(P>0.05),对照组PCI术后CK-MB及cTnI较试验组明显升高(P<0.01)。试验组PCI术后CK-MB和cTnI升高1～3倍和>3倍的比例均明显低于对照组(P<0.05,P<0.01)。结论冠心病患者PCI术后即刻给予外源性磷酸肌酸有助于减少心肌损伤。
Objective To evaluate the effect of exogenous creatine phosphate supplementation on myocardial injury after PCI. Methods A total of 200 coronary heart disease patients undergoing PCI were enrolled and randomly divided into experimental group and control group with 100 cases in each group. In the control group, the routine treatment regimen recommended by the guidelines was used. On the basis of routine treatment, the experimental group received intravenous infusion of sodium creatine phosphate immediately after operation for 2 times / d and 2 g / time for 3 consecutive days. The levels of CK-MB and cTnI were detected in all patients before PCI and 3 days after PCI. Results There was no significant difference in CK-MB and cTnI before PCI between experimental group and control group (P> 0.05). CK-MB and cTnI in control group were significantly higher than those in experimental group (P <0.01). The ratio of CK-MB and cTnI increased by 1 to 3 times and> 3 times after PCI in experimental group were significantly lower than those in control group (P <0.05, P <0.01). Conclusions Exogenous creatine phosphate may be helpful to reduce myocardial injury in patients with coronary heart disease after PCI.