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目的探讨T2DM患者血清胎盘生长因子(PLGF)与颈动脉粥样硬化(CAS)的关系。方法采用ELISA检测T2DM组、T2DM+CAS组及NC组血清PLGF、FPG、血脂、FIns、HbA1c、高敏C反应蛋白(hsC-RP)、TNF-α及IL-6水平,计算BMI和胰岛素抵抗指数(HOMA-IR)。结果T2DM、T2DM+CAS组血清PLGF水平均高于NC组[(45.35±13.00),(59.24±11.05)vs(27.30±10.22)pg/ml](P<0.01)。T2DM+CAS组血清PLGF水平高于T2DM组(P<0.01)。T2DM组血清PLGF水平与TC、LDL-C、hsC-RP、IL-6呈正相关。LDL-C、IL-6是血清PLGF水平的独立影响因素。PLGF是发生CAS风险的预测因素。结论 T2DM合并CAS患者血清PLGF高于正常人和单纯T2DM患者,且与慢性炎症相关。PLGF可能参与了T2DM患者CAS的发生发展。
Objective To investigate the relationship between serum placental growth factor (PLGF) and carotid atherosclerosis (CAS) in patients with T2DM. Methods Serum levels of PLGF, FPG, lipids, FIns, HbA1c, hsC-RP, TNF-α and IL-6 in T2DM group, T2DM + CAS group and NC group were measured by ELISA. BMI and insulin resistance index (HOMA-IR). Results The serum levels of PLGF in T2DM and T2DM + CAS groups were significantly higher than those in NC group (45.35 ± 13.00 vs 59.24 ± 11.05 vs 27.30 ± 10.22 pg / ml, P <0.01). The level of PLGF in T2DM + CAS group was higher than that in T2DM group (P <0.01). Serum levels of PLGF in T2DM group were positively correlated with TC, LDL-C, hsC-RP and IL-6. LDL-C, IL-6 is an independent factor of serum PLGF level. PLGF is a predictor of CAS risk. Conclusions The serum PLGF in patients with T2DM complicated with CAS is higher than that in normal people and simple T2DM patients, and is associated with chronic inflammation. PLGF may be involved in the occurrence and development of CAS in T2DM patients.