50年代初,Markowitz提出了肝动脉结扎(HAL)治疗肝癌的概念。其后的临床应用表明,此法可导致肝癌细胞的大量坏死,使不能手术的肝癌患者生存期延长。70年代中期兴起的肝动脉栓塞术(HAE)它是HAL的进一步发展。肝动脉血流阻断治疗肝癌的理论依据正常肝脏接受肝动脉和门静脉双重血液供应,而肝肿瘤的血供90～95％来自肝动脉,当 In the early 1950s, Markowitz proposed the concept of hepatic artery ligation (HAL) for liver cancer. Subsequent clinical application showed that this method can lead to a large number of necrosis of liver cancer cells, extending the survival of patients with inoperable liver cancer. The rise of the hepatic artery embolization (HAE) in the mid-1970s is a further development of HAL. The theoretical basis for hepatic arterial blood flow blockade for hepatocellular carcinoma The normal hepatic artery receives hepatic artery and portal vein dual blood supply, while the hepatic tumor blood supply is 90-95% from the hepatic artery.