急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)的发生机制异常复杂,缺乏有效治疗手段。近年来研究表明,他汀类药物除具有降低胆固醇作用之外,还有许多非调脂作用,包括抑制炎症介质的释放和血小板的聚集、抗凝、抗氧化、改善血管内皮功能、稳定动脉粥样硬化斑块、抑制系膜细胞增生和免疫调节反应等。他汀药类药物的非调脂作用可能对ALI患者的 The pathogenesis of acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is extremely complex and lacks an effective treatment. In recent years, studies have shown that in addition to statin cholesterol lowering effect, there are many non-lipid-lowering effects, including the inhibition of inflammatory mediators and platelet aggregation, anticoagulant, anti-oxidation, improve endothelial function, stable atherosclerosis Sclerosis plaque, inhibit mesangial cell proliferation and immune regulation reaction. The non-lipid-lowering effects of statin drugs may be in patients with ALI