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目的:探讨乙型肝炎病毒(HBV)感染者血清中白介素-32(IL-32)水平的变化及其临床意义。方法:对100例HBV感染者和30例健康者检测外周血清白细胞介素-32(IL-32)的含量,比较IL-32水平变化的规律,并分析其与临床疾病谱和HBV复制水平的关系。结果:(1)急性乙型肝炎、中度慢性乙型肝炎、重度慢性乙型肝炎患者血清IL-32水平与对照组有显著性差异(P<0.001);轻度慢性乙型肝炎患者血清IL-32水平高于健康对照组,但无统计学意义(P>0.05);急性乙型肝炎、中、重度慢性乙型肝炎患者血清IL-32水平均显著高于轻度慢性乙型肝炎组,且有统计学意义(P<0.001);急性乙型肝炎、重度慢性乙型肝炎患者血清IL-32水平均高于中度慢性乙型肝炎组,有统计学意义(P<0.001);急性乙型肝炎、重度慢性乙型肝炎组之间无明显差异(P>0.05)。(2)HBV感染者HBV-DNA阳性组IL-32水平较阴性组为高,但无差异;高、中、低病毒载量组之间血清IL-32水平也无差异(P>0.05)。(3)慢性乙型肝炎患者不同ALT水平组血清IL-32水平均高于对照组(P<0.05);且低、中、高ALT水平组之间与IL-32水平也有统计学意义;IL-32水平与ALT水平正相关。结论:HBV感染可导致机体血清IL-32水平的变化,且随炎症加重呈上升趋势,证实IL-32在炎症反应中发挥重要作用,IL-32可能参与了慢性HBV感染者肝组织损伤及病情发展的过程。血清IL-32水平变化与HBV复制水平无关。
Objective: To investigate the changes of serum interleukin-32 (IL-32) level in patients with hepatitis B virus infection and its clinical significance. Methods: The levels of interleukin-32 (IL-32) in peripheral blood were detected in 100 cases of HBV infection and 30 cases of healthy subjects. The changes of IL-32 levels were compared with those of clinical samples and HBV replication levels relationship. Results: (1) Serum IL-32 levels in patients with acute hepatitis B, moderate chronic hepatitis B and severe chronic hepatitis B were significantly different from those in the control group (P <0.001). Serum IL levels in patients with mild chronic hepatitis B -32 in patients with acute hepatitis B, moderate and severe chronic hepatitis B were significantly higher than those in patients with mild chronic hepatitis B, but no significant difference (P> 0.05) (P <0.001). Serum IL-32 levels in patients with acute hepatitis B and severe chronic hepatitis B were significantly higher than those with moderate chronic hepatitis B (P <0.001) Hepatitis B and severe chronic hepatitis B had no significant difference (P> 0.05). (2) The level of IL-32 in HBV-DNA positive group was higher than that in negative group, but there was no difference between the two groups. There was no difference in serum IL-32 level between high, medium and low viral load groups (P> 0.05). (3) Serum IL-32 levels in ALT patients with chronic hepatitis B were significantly higher than those in control subjects (P <0.05); IL-32 levels were also significantly different between low, middle and high ALT groups; IL -32 level is positively correlated with ALT level. Conclusion: HBV infection can lead to the change of serum IL-32 level, and with the increase of inflammation, it is confirmed that IL-32 plays an important role in the inflammatory reaction. IL-32 may be involved in the liver damage and the condition of chronic HBV infection Development process. Serum IL-32 levels and HBV replication level has nothing to do.