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目的探讨乌拉地尔联合硝酸甘油控制体外循环期间高血压的疗效。方法选取2010年8月~2016年1月我院手术治疗的患者102例作为研究对象,将其随机分为观察组与对照组,各51例。对照组单纯给予硝酸甘油治疗,观察组给予乌拉地尔联合硝酸甘油治疗,比较两组疗效。结果观察组用药后SBP、DBP、HR水平均优于对照组(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论手术患者体外循环期间应用乌拉地尔联合硝酸甘油治疗的降压效果较好,且减少单独药物产生的耐受。
Objective To investigate the efficacy of urapidil combined with nitroglycerin in controlling hypertension during cardiopulmonary bypass. Methods A total of 102 patients undergoing surgery in our hospital from August 2010 to January 2016 were selected as study subjects and randomly divided into observation group and control group, with 51 cases in each group. The control group was treated with nitroglycerin alone. The observation group was treated with urapidil plus nitroglycerin. The curative effect was compared between the two groups. Results The levels of SBP, DBP and HR in the observation group were better than those in the control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusions The use of Urapidil in combination with nitroglycerin during cardiopulmonary bypass has a better antihypertensive effect and reduces the tolerance of drug alone.