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对原发性肝癌(PLC)的研究,尤其是在临床病理学方面进行的研究以日本最为活跃,并卓有成效,值得我们借鉴。现将1985年以来的资料综述如下:一、发病率日本 PLC 发病率,特别是男性肝细胞癌(HCC),在过去的25年中有急剧增长的趋势。据日本尸检登记处统计,每年约有4万人死于 PLC。HCC 在全部恶性肿瘤中,从1958年的6%上升到1983年的14%。在大阪府癌症登记中亦显示同样增长的趋势。Okuda 认为其原因,可能与战后医疗条件改善,注射、接种、输血等传播非甲非乙型肝炎的机会增多,以及滥用药物和酗酒有关。二、癌前期病变Mallory 小体(MB)可发生于各种肝病中,近来有些学者通过动物实验认为,MB 可能是癌前期病变。
The study of primary liver cancer (PLC), especially in the field of clinical pathology, is most active in Japan and it is highly effective. It is worth learning from. The data from 1985 onwards are summarized as follows: I. Incidence The incidence of PLC in Japan, especially male hepatocellular carcinoma (HCC), has shown a sharp increase in the past 25 years. According to statistics from the Japanese Autopsy Registry, about 40,000 people die each year from PLC. HCC rose from 6% in 1958 to 14% in 1983 in all malignancies. The same growing trend has also been shown in the Osaka Cancer Registry. Okuda believes that the reasons may be related to improved post-war medical conditions, increased opportunities for the spread of non-A/N hepatitis B such as injections, vaccination, and blood transfusion, as well as drug abuse and alcohol abuse. Second, premalignant lesions Mallory body (MB) can occur in a variety of liver diseases, some recent scholars believe that MB may be precancerous lesions through animal experiments.