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目的:初步探讨强化区最大单径之和变化在评价肺癌非手术疗效中的作用。方法:22例经非手术治疗肺癌患者在治疗前及停止治疗1个月后行螺旋CT增强双期扫描。结果:治疗前、治疗后及治疗后90 s时病灶强化区最大单径之和差异有统计学意义(F=4.273,P=0.018)。治疗前病灶最大单径之和明显大于治疗后病灶强化区最大单径之和(P=0.005),与治疗后最大单径之和比较,差异无统计学意义(P=0.203)。治疗后最大单径之和与治疗后病灶强化区最大单径之和比较,差异无统计学意义(P=0.108)。结论:利用肿瘤最大单径之和变化来评价肺癌疗效会低估治疗效果,建议利用强化区最大单径之和变化来评价肺癌疗效。
OBJECTIVE: To investigate the role of the sum of the largest single diameters in the intensive area in the evaluation of non-surgical treatment of lung cancer. Methods: Twenty-two non-surgical patients with lung cancer underwent double-phase spiral CT before treatment and one month after stopping treatment. Results: There was significant difference in the maximum single diameter before treatment, after treatment and 90 s after treatment (F = 4.273, P = 0.018). The sum of the largest single diameters of lesions before treatment was significantly larger than that of the largest single diameter of lesions after enhancement (P = 0.005). There was no significant difference between them (P = 0.203). There was no significant difference between the sum of the largest single diameter after treatment and the sum of the largest single diameter of the focal enhancement area after treatment (P = 0.108). Conclusions: The evaluation of lung cancer efficacy by evaluating the sum of the maximum single pathological diameters of tumors will underestimate the therapeutic effect. It is suggested that the change of the maximum single path of the intensive area should be used to evaluate the efficacy of lung cancer.