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为探讨糖基化终产物在糖尿病大鼠动脉粥样硬化发生中对主动脉细胞外基质成分生成增加所起的作用，本实验将糖尿病大鼠、糖尿病＋ 氨基胍治疗大鼠和正常大鼠分别喂养１、２、３ 和４ 个月后，测定其血红蛋白－ 糖基化终产物及主动脉壁Ⅲ型前胶原、Ⅳ型胶原、Ⅳ型胶原－ 糖基化终产物及层粘蛋白含量。结果发现，糖尿病组大鼠各时相点血红蛋白－ 糖基化终产物（１ ～４ 个月分别为６．８８±１ ．２３、１０ ．２６±０．６３、１５．３±１．４９ 和１８．５７ ±２．９０ ｋｕｇ， 与血糖水平相关）、Ⅲ型前胶原（１ ～４个月分别为１５．２０±３．０３ 、２１．４４ ±１．７９、２７．１９±３ ．２８ 和３３．９９±４ ．９６ μｇＬ， 与血红蛋白－ 糖基化终产物和Ⅳ型胶原－ 糖基化终产物相关） 、Ⅳ型胶原（１～４ 个月分别为２３．６７±１．４９、３０．３７ ±２ ．８６、３６．６５ ±１．９８ 和４５．４６±５．７７ μｇＬ， 与血红蛋白－ 糖基化终产物和Ⅳ型胶原－ 糖基化终产物相关）、Ⅳ型胶原－ 糖基化终产物（１～４ 个月分别为０．７９ ±０．１５、１．２５ ±０．２２ 、１．５４ ±０．０６ 和１．８０±０ ．１４ Ｍｕｇ， 与血红蛋白－ 糖基化终产物和Ⅳ型胶原相关） ?
In order to explore the effect of advanced glycation end products on the formation of extracellular matrix components of aortic extracellular matrix in the development of atherosclerosis in diabetic rats, the diabetic rats, diabetic + aminoguanidine-treated rats and normal rats After 1, 2, 3 and 4 months of feeding, the hemoglobin-glycosylation end products and aorta type III procollagen, type IV collagen, type IV collagen-glycosylation end products and laminin were measured. The results showed that the hemoglobin-glycosylation end products (1 ~ 4 months, respectively, 6.88 ± 1.23, 10.26 ± 0.63, 15.3 ± 1.49 and 18.57 ± 2.90 kug), and type Ⅲ procollagen (1.20 ± 3.03, 21.44 ± 1.79 and 27.19 ± 3 .28 and 33.99 ± 4.96 μg L, respectively, associated with hemoglobin-glycosylation end products and type IV collagen-glycosylation end products), type IV collagen (1 to 4 months, respectively, 23.67 ± 1.49, 30.37 ± 2 .86, 36.65 ± 1.98, and 45.46 ± 5.77 μg L, correlating with hemoglobin-glycated end products and collagen type IV-glycosylation end products ), Type IV collagen - advanced glycation end products (1 ~ 4 months were 0.79 ± 0.15, 1.25 ± 0.22, 1.54 ± 0.06 and 1.80 ± 0.1 4 Mug, associated with hemoglobin-glycated end products and collagen type Ⅳ)?