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目的:分析研究甘精胰岛素与阿卡波糖联合治疗老年2型糖尿病的治疗效果。方法:从2011年2月到2014年2月在我院治疗的2型糖尿病高龄患者中选取68例,随机分成采取甘精胰岛素与阿卡波糖联合治疗的观察组(34例)与采取预混胰岛素治疗的对照组(34例),观察组每晚22:00点给予1次甘精胰岛素进行皮下注射,并给予阿卡波糖于每日三餐第一口饭时嚼服,对照组于每日早晚进食前的30min给予预混胰岛素进行皮下注射,两组均治疗12周。观察两组患者治疗4、8、12周的FBG空腹血糖,2hPBG餐后2h血糖等指标变化与低血糖情况。结果:两组空腹与餐后血糖均较治疗前有显著下降,同时采用甘精胰岛素与阿卡波糖联合治疗的观察组,其空腹、餐后血糖以及低血糖发生率均小于对照组(p<0.05)。结论:甘精胰岛素与阿卡波糖联合治疗老年2型糖尿病具有良好质量效果,同时可有效减少低血糖发生,值得推广。
Objective: To analyze the therapeutic effect of insulin glargine and acarbose in the treatment of type 2 diabetes in the elderly. Methods: From February 2011 to February 2014, 68 elderly patients with type 2 diabetes mellitus treated in our hospital were randomly divided into observation group (34 cases) treated with combination of insulin glargine and acarbose and control group In the control group (34 cases) treated with mixed insulin, glargine was administered subcutaneously once a day at 22:00 in the observation group and acarbose was chewed on the first meal of three meals a day, while in the control group Pre-mixed insulin was administered subcutaneously 30 minutes before and after daily morning and evening meals, both for 12 weeks. The FBG fasting blood glucose, 2hPBG 2h postprandial blood glucose and other indicators changes and hypoglycemia in two groups were observed. Results: Both fasting and postprandial blood glucose in both groups decreased significantly compared with those before treatment. The fasting and postprandial blood glucose and hypoglycemia in the observation group treated with insulin glargine and acarbose were significantly lower than those in the control group (p <0.05). Conclusion: The combination of insulin glargine and acarbose in the treatment of type 2 diabetes mellitus has good quality results, and can effectively reduce the incidence of hypoglycemia, which is worth promoting.