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目的:探讨肠内营养乳剂TPF对高龄伴吞咽困难病人的应用价值。方法:将60例≥80岁伴吞咽困难的病人随机分为治疗组和对照组,每组各30例。病人于入院后48 h内分别给予鼻饲肠内营养乳剂TPF(瑞先)和普通鼻饲饮食,治疗1个月后,观察两组病人的营养指标(血清清蛋白、前清蛋白、血红蛋白、体重指数)、细胞免疫指标(CD3+、CD4+、CD8+)和血液生化指标(肝肾功能、血糖)等的变化。结果:治疗组病人血清清蛋白、前清蛋白、体重指数等明显高于对照组(P<0.05);CD4+、CD4+/CD8+比值等指标明显改善(P<0.05),CD3+增加更显著(P<0.01);肝肾功能、血糖等生化指标未见明显变化(P>0.05)。结论:合理的肠内营养乳剂TPF支持治疗,能改善高龄伴吞咽困难病人的营养状况和免疫功能,促进病人康复。
Objective: To investigate the value of enteral nutrition emulsion TPF in elderly patients with dysphagia. Methods: Sixty patients with dysphagia aged ≥80 years were randomly divided into treatment group and control group, with 30 cases in each group. Patients were given intranasal enteral nutrition emulsion TPF (Ruixian) and ordinary nasal feeding diet within 48 hours after admission. After treatment for 1 month, the nutritional indexes (serum albumin, prealbumin, hemoglobin, body mass index ), Cellular immune indicators (CD3 +, CD4 +, CD8 +) and blood biochemical indicators (liver and kidney function, blood glucose) and so on. Results: Serum albumin, prealbumin, body mass index were significantly higher in the treatment group than those in the control group (P <0.05). The indexes of CD4 + and CD4 + / CD8 + were significantly improved and the CD3 + 0.01). There was no significant change in biochemical indexes such as liver and kidney function and blood glucose (P> 0.05). Conclusion: The reasonable enteral nutrition emulsion TPF supportive therapy can improve the nutritional status and immune function of elderly patients with dysphagia and promote the recovery of patients.