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目的观察中枢神经系统(CNS)感染患者血清中可溶性细胞间粘附分子-1(sICAM-1)和肿瘤坏死因子-α(TNF-α)的水平变化并探讨其临床意义。方法采用双抗体酶联免疫吸附法(ELISA)分别检测病毒性脑炎28例,细菌性脑膜炎24例的病人在急性期和恢复期血清中sICAM-1和TNF-α含量并与25例健康对照组比较。结果在急性期CNS感染各组血清中sICAM-1和TNF-α水平显著高于对照组(P<0.01),细菌性脑膜炎组血清中sICAM-1和TNF-α水平显著高于病毒性脑炎组(P<0.01)。在恢复期CNS感染各组血清中sICAM-1和TNF-α含量与对照组比较无明显差异(P>0.05)。结论sICAM-1和TNF-α参与了中枢神经系统感染的病理过程,与病程密切相关,可作为细菌性脑膜炎与病毒性脑炎的鉴别诊断指标。
Objective To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1) and tumor necrosis factor-α (TNF-α) in patients with central nervous system (CNS) infection and to explore its clinical significance. Methods Serum levels of sICAM-1 and TNF-α in 28 patients with viral encephalitis and 24 patients with bacterial meningitis were determined by ELISA and 25 healthy individuals Comparison of the control group. Results Serum levels of sICAM-1 and TNF-α were significantly higher in CNS infection group than those in control group (P <0.01). Serum levels of sICAM-1 and TNF-α in bacterial meningitis group were significantly higher than those in viral brain Yan group (P <0.01). There was no significant difference in serum sICAM-1 and TNF-α levels between the two groups during the recovery period (P> 0.05). Conclusions sICAM-1 and TNF-α are involved in the pathological process of CNS infection and are closely related to the course of the disease. They can be used as a differential diagnosis marker of bacterial meningitis and viral encephalitis.