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目的探讨冠心病合并2型糖尿病患者冠状动脉造影时伴有造影剂滞留现象与其血清高敏C反应蛋白的关系。方法根据冠状动脉造影结果,分成冠状动脉造影正常健康组、冠状动脉造影正常的2型糖尿病组和存在造影剂滞留组。冠状动脉造影采用标准术式,取右侧股动脉为穿刺入路,造影剂采用低渗非离子型。统计学分析应用SPSS 11.0统计软件包。结果Hs-CRP水平正常对照组为(0.9±0.6)mg/L,冠状动脉造影正常的糖尿病组为(2.1±1.4)mg/L,造影剂滞留组为(4.4±1.9)mg/L,冠状动脉造影正常的糖尿病组和造影剂滞留组明显高于正常对照组(分别为P<0.05,P<0.01);冠状动脉造影正常的糖尿病组和造影剂滞留组hs-CRP水平差异也有统计学意义(P<0.01);冠状动脉造影时有造影剂滞留组,其血清高敏C反应蛋白浓度水平明显高于冠状动脉造影正常人的血清浓度水平(P<0.01)。结论血清hs-CRP水平与冠心病合并2型糖尿病冠脉病变密切相关,在冠脉粥样硬化的过程中有炎症反应参与。冠状动脉造影有造影剂滞留处的血管可能存在易损斑块,而该处病变血管可能是急性冠脉综合征患者的“罪犯”血管。
Objective To investigate the relationship between contrast-agent retention and serum high-sensitivity C-reactive protein in patients with coronary heart disease complicated with type 2 diabetes undergoing coronary angiography. Methods According to coronary angiography results, divided into normal healthy coronary angiography group, normal coronary angiography type 2 diabetes group and presence of contrast agent retention group. Coronary angiography using standard surgical procedures, take the right femoral artery puncture approach, contrast agent using low permeability non-ionic. Statistical analysis using SPSS 11.0 statistical package. Results The level of Hs-CRP was (0.9 ± 0.6) mg / L in normal control group, (2.1 ± 1.4) mg / L in diabetic group with normal coronary angiography, and (4.4 ± 1.9) mg / There was also a significant difference in hs-CRP levels between diabetic group with normal angiography and contrast medium retention group and normal contrast group (P <0.05, P <0.01, respectively) (P <0.01). The concentration of high-sensitivity C-reactive protein in patients with coronary artery angiography was significantly higher than that of normal controls (P <0.01). Conclusions Serum hs-CRP level is closely related to coronary artery disease in patients with type 2 diabetes mellitus and coronary artery disease. There is inflammation involved in the process of coronary atherosclerosis. Coronary angiography There may be vulnerable plaque in the vessels at the contrast reservoirs where the diseased vessels may be “criminals” vessels in patients with acute coronary syndromes.