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[目的]调查患有或不患有氯痤疮的三氯苯酚(tri-chlorophenol,TCP)或五氯苯酚(pentachlorophenol,PCP)接触工人血清的二恶英水平,并观察患氯痤疮工人的特征。[方法]收集26名PCP工人、12名TCP工人和36名没有PCP和TCP暴露史工人的血样,并测定二恶英含量。氯痤疮的确定根据工厂医疗记录。[结果]PCP工人中,患氯痤疮与未患氯痤疮的工人相比具有更高毒性当量(根据世界卫生组织)的2378-TCDD,12378-PeCDD,123678-H6CDD,123789-H6CDD和123678-H6CDF水平。而在TCP工人中,虽然曾患有氯痤疮的工人血清中2378-TCDD水平较高,但与未患有氯痤疮者的血清水平上并无明显差异。氯痤疮的公认危险因素有首次暴露年龄较小和距第一次暴露的时间较长等,但仅在接触TPC工人中得到证实。PCP工人患氯痤疮和诊断前较长的接触时间相关。[结论]氯痤疮是二恶英高暴露的良好指标。TCP和PCP接触工人的血清二恶英同系物具有明显不同的特点。
[Purpose] To investigate the level of dioxin exposure to workers’ serum with tri-chlorophenol (TCP) or pentachlorophenol (PCP) with or without acne and to observe the characteristics of workers with chlorococcosis. [Method] The blood samples of 26 PCP workers, 12 TCP workers and 36 workers without PCP and TCP exposure were collected and the dioxin content was measured. Chloramphenicol is based on factory medical records. [Results] Among PCP workers, 2378-TCDD, 12378-PeCDD, 123678-H6CDD, 123789-H6CDD, and 123678-H6CDD with chlorofluorocarbons with higher toxic equivalents (according to the World Health Organization) Level. Among workers with TCP, however, serum levels of 2378-TCDD were higher in workers who had had chlorinated acne, but were not significantly different from those in those who did not. The recognized risk factors for chronic acne are younger at first exposure and longer exposure to the first exposure, but are only confirmed in exposure to TPC workers. Cholesterol acne is associated with longer PCP exposure time before diagnosis. [Conclusion] Chloramphenicol is a good indicator of high dioxin exposure. Serum dioxin homologues from workers exposed to TCP and PCP have distinctly different characteristics.