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目的 :探索用我院自行改良人工肾机进行血液滤过 ( HF)、血液灌流 ( H P)、血浆分离( PP)、血液透析 ( HD)的不同组合 ,观察该人工肝支持系统 ( AL SS)治疗由各种病因引起的肝肾功能不全的临床应用疗效 ,并研究其机理。方法 :选择符合本文肝肾功能不全条件的住院患者 30例 ,随机分为治疗组和对照组 ,各 15例 ,在年龄、性别、病情方面有可比性。治疗组用 A LSS治疗 ,对照组用血液透析 ( HD)治疗 ,两组基础疗法相同。治疗前后观察主要自觉症状变化 ,检测血电解质 ,酸中毒 ,病毒含量 ,内毒素 ,血气分析 ,肝肾功能 ,氨基酸谱等。比较不同病情患者的疗效。结果 :治疗组经 A LSS治疗后 ,患者自觉症状 ,离子紊乱 ,酸中毒 ,肝肾功能有显著改善 ,血胆红素等中分子物质 ,血氨 ,内毒素水平明显降低 ( P<0 .0 5) ,治疗好转率为 73.3% ,高于对照组 ( P<0 .0 5) ,提示早做成功率更高。结论 :AL SS治疗肝肾不全疗效可靠 ,治疗时机应在早中期
Objective: To explore different combinations of hemodialysis (HF), hemoperfusion (HP), plasma separation (PP) and hemodialysis (HD) with artificial kidney machine modified by our hospital. The artificial liver support system (ALSS) Treatment of various causes of liver and kidney dysfunction clinical application of efficacy, and study its mechanism. Methods: Thirty patients with inpatients with hepatorenal insufficiency were randomly divided into treatment group (n = 15) and control group (n = 15), which were comparable in age, gender, and disease. The treatment group with A LSS treatment, the control group with hemodialysis (HD) treatment, the two groups of basic therapy the same. Before and after treatment to observe the main symptoms of change, detection of blood electrolyte, acidosis, virus content, endotoxin, blood gas analysis, liver and kidney function, amino acid spectrum. Compare the efficacy of different disease patients. Results: After treatment with ALSS, the patients’ symptoms, ion disorders, acidosis and liver and kidney function were significantly improved, and the contents of blood bilirubin and other substances, blood ammonia and endotoxin were significantly decreased (P <0. 0 5). The improvement rate of treatment was 73.3%, which was higher than that of the control group (P <0.05), suggesting that the success rate of early treatment was higher. Conclusion: The treatment of liver and kidney failure with AL SS is reliable and the timing of treatment should be in the early and middle stages