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造血干细胞(haematopoietic stem cells,HSCs)具有自我更新功能,可分化成多系血细胞。微环境、活性氧(reactive oxidative species,ROS)、细胞周期调控分子和能量代谢等对HSCs的稳态具有调节作用。抑癌基因Lkb1,又名STK11(serine threonine protein kinase 11),在多种细胞内磷酸化激活蛋白激酶AMPK(AMP-activated protein kinase),调节机体代谢和细胞增殖。近期研究发现,Lkb1在HSCs的代谢调控及稳态维持中发挥重要作用。对Lkb1在HSCs数量、功能、代谢的稳态维持中的作用研究进展进行综述。
Hematopoietic stem cells (HSCs) are self-renewal and can differentiate into multiple blood cells. Microenvironment, reactive oxidative species (ROS), cell cycle regulatory molecules and energy metabolism have a regulatory effect on the homeostasis of HSCs. Tumor suppressor gene Lkb1, also known as STK11 (serine threonine protein kinase 11), phosphorylates AMP-activated protein kinase (AMPK) in many kinds of cells to regulate body metabolism and cell proliferation. Recent studies have found that Lkb1 plays an important role in the metabolic regulation and homeostasis of HSCs. This review summarizes the research progress of Lkb1 in the homeostasis of the quantity, function and metabolism of HSCs.