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甲膦酸三钠(foscarnet,trisoudium phbsphonoformate)是一种治疗严重巨细胞病毒(CMV)感染的尚在评价中的药物,也是逆转录酶(RT)抑制剂之一,并正被考虑作为AIDS相关性病毒HTLV Ⅲ/LAV的抑制剂。1924年该药由Nylen首先合成,1979年有人报告该药能抑制流行性感冒病毒的RNA聚合酶,进一步研究提示该药尚可抑制其他病毒的酶(尤其是多种逆转录病毒的RT和单纯疱疹病毒I型、Ⅱ型及CMV的DNA聚合酶)活性。中等浓度(32～55μmol/L)即可抑制α-DNA聚合酶。对病
Foscarnet (trisoudium phsphonoformate), a currently under evaluation for the treatment of severe cytomegalovirus (CMV) infection, is also one of the reverse transcriptase (RT) inhibitors and is being considered as an AIDS-related Inhibitors of the sex virus HTLV III / LAV. The drug was first synthesized by Nylen in 1924, and in 1979 it was reported that the drug inhibited the RNA polymerase of influenza virus. Further research suggests that the drug can still inhibit other viral enzymes (especially RT of multiple retroviruses and simple Herpes virus type I, type II and CMV DNA polymerase) activity. Medium concentrations (32 ~ 55μmol / L) can inhibit α-DNA polymerase. Right sick