吡喹酮治疗曼氏血吸虫病患者引起的血性腹泻已有报道(Polderman,1984)。作者在菲律宾对吡喹酮进行药代动力学研究时发现日本血吸虫病患者经吡喹酮治疗后发生类似的综合症。20例研究对象均为有不同程度肝损害的日本血吸虫病患者,其中4例用吡喹酮后发生血性腹泻。为了进行药代动力学研究,所有患者服吡喹酮20mg/kg 3次,每次间隔30分钟,总剂量60mg/kg。目前所推荐的治疗日本血吸虫病方案之一,早餐及午餐 Praziquantel has been reported to treat bloody diarrhea in patients with Schistosoma mansoni (Polderman, 1984). In the Philippines, the pharmacokinetics study of praziquantel found that a similar syndrome occurred in patients with schistosomiasis japonica after praziquantel treatment. Twenty patients were all schistosomiasis japonica patients with varying degrees of liver damage, of whom 4 had bloody diarrhea after praziquantel treatment. For pharmacokinetic studies, all patients received praziquantel 20 mg / kg 3 times at intervals of 30 minutes for a total dose of 60 mg / kg. Currently recommended for treatment of schistosomiasis japonicus program, breakfast and lunch