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巢蛋白(nestin)是第Ⅵ类中间丝蛋白,主要在胚胎期神经前体细胞和神经干细胞一过性表达。在正常细胞演变成肿瘤细胞过程中,巢蛋白又呈现返祖性表达。近年来研究发现nestin阳性细胞散在的分布于垂体的前叶、中间部和神经部。但这些nestin阳性细胞是否包括了垂体前体细胞还不清楚。在垂体腺瘤的部分毛细血管内皮细胞中也检测到nestin的表达,推测它可作为垂体血管发生的一种检测指标。
Nestin is a type VI intermediate silk protein that is transiently expressed primarily in embryonic neural precursor cells and neural stem cells. In the process of normal cells evolving into tumor cells, nidogen also exhibits retrograde expression. In recent years, we found that nestin-positive cells scattered in the anterior pituitary, middle and neurons. Whether these nestin-positive cells include pituitary precursor cells is unclear. The expression of nestin was also detected in some capillary endothelial cells of pituitary adenoma, suggesting that it could be used as a detection index of pituitary angiogenesis.