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实验用不同浓度的生长激素（h-GH）作用于培养的下丘脑神经细胞，观察其对细胞发育和衰老的影响，发现h-GH能促进培养细胞存活、发育，增加突起长度和细胞平均面积，并促进网络的形成，较高浓度的h-GH（5～10mg／L）均导致发育期及成熟期中的培养细胞寿命明显缩短，较低浓度（1mg／L）h－GH对发育中的细胞寿命无明显作用，但能显著延长成熟期细胞的寿命。适量h-GH有延长细胞寿命的作用，而过量则促进细胞迅速出现衰老特征性变化；如大量脂褐素形成，神经元纤维增生及线粒体肿胀、变性，跑体中出现空泡，细胞器减少等细胞衰老常见的特征。这些病理性变化常为衰老神经元的特征性表现。因此h－GH等因子在细胞蛋白质代谢中的平衡失调，可能在细胞衰老发展过程中起一定作用。
The effect of different concentrations of growth hormone (h-GH) on cultured hypothalamus neurons was observed and the effect of h-GH on the survival and development of cultured cells was observed. The length and the average cell area , And promoted the formation of network. Higher concentrations of h-GH (5 ~ 10 mg / L) resulted in markedly shortened the lifespan of cultured cells during the development and the maturation stages. The effects of lower concentration of h-GH Cell life has no significant effect, but can significantly extend the maturity of cell life. Appropriate amount of h-GH has the effect of prolonging the life span of cells, while overdose promotes the rapid characteristic changes of cells. For example, a large amount of lipofuscin is formed, neurofibrillary proliferation and mitochondria are swollen and degenerated, vacuoles and organelles are reduced in the running body Common features of cellular aging. These pathological changes are often characteristic of aging neurons. So h-GH and other factors in cellular protein metabolism imbalance, may play a role in the process of cellular senescence.