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1901年Frohlich首先记载本病,其主要特点为肥胖、生殖腺及生殖器萎缩、第二性征缺乏以及代谢降低。临床表现为头痛、呕吐、视力障碍、体温改变、嗜睡、智力障碍、以及常有多尿的现象。当时Frohlich报告1例,系14岁男孩,肥胖并有性器官发育不良,经外科手术,诊断为垂体肿瘤。后人遂称这类疾病为Frohlich综合病征。1906年Bartel发现垂体未损环坏而下视丘损坏的病人有相似表现,故名为肥胖性生殖无能症。1921年Bailey研究狗的尿崩症,发现损及下视丘后狗有肥胖现象,后为Smith及Ranson等证实。1939年Frohlich承认1901年他以为
1901 Frohlich first documented the disease, the main features of obesity, gonads and genital atrophy, lack of secondary sexual characteristics and reduced metabolism. Clinical manifestations of headache, vomiting, visual impairment, temperature changes, drowsiness, mental retardation, and often polyuria phenomenon. At that time, Frohlich reported 1 case, a 14-year-old boy with obesity and sexual dysplasia. After surgery, he was diagnosed as a pituitary tumor. Descendants have referred to these diseases as Frohlich syndrome. In 1906, Bartel found that patients with pituitary lesions without damage and hypothalamic lesions had similar symptoms, hence the name obesity genital incontinence. In 1921, Bailey studied the diabetes insipidus in dogs and found that the dogs suffered from obesity after hypophysectomy. Later confirmed by Smith and Ranson et al. In 1939 Frohlich admitted in 1901 that he thought