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目的研究老年慢性心力衰竭(CHF)患者血浆内皮素-1、血清Ⅰ型前胶原羧基端肽(PⅠCP)、Ⅲ型前胶原氨基端肽(PⅢNP)含量的变化及其临床意义。方法采用放射免疫分析法分别测定心衰患者血浆内皮素-1(ET-1)、PⅠCP和PⅢNP含量,同时用心脏多普勒超声检查心脏左心房内径、LVEF%,研究血浆ET-1、PⅠCP、PⅢNP的含量变化及相关性。结果心衰患者ET-1、PⅠCP、PⅢNP含量较对照组明显升高(P<0.05或P<0.01);且ET-1与血清PⅠCP、PⅢNP含量均呈显著正相关(r=0.574,P<0.01;r=0.596,P<0.01),血清PⅠCP与PⅢNP含量也呈正相关(r=0.688,P<0.01)。结论老年心衰患者ET-1、PⅠCP、PⅢNP含量增加,内皮素与心肌纤维化密切相关。
Objective To study the changes of plasma endothelin - 1, serum type Ⅰ procollagen carboxyterminal peptide (PⅠCP) and type Ⅲ procollagen aminoterminal peptide (PⅢNP) in elderly patients with chronic heart failure (CHF) and its clinical significance. Methods Plasma endothelin-1 (ET-1), PⅠCP and PⅢNP levels were measured by radioimmunoassay. The left atrium and LVEF% were measured by Doppler echocardiography, and plasma levels of ET-1, PⅠCP , PⅢNP content changes and correlations. Results The levels of ET-1, PⅠCP and PⅢNP in patients with heart failure were significantly higher than those in the control group (P <0.05 or P <0.01), and there was a significant positive correlation between the levels of ET-1 and PⅠCP and PⅢNP (r = 0.01; r = 0.596, P <0.01). There was also a positive correlation between serum PⅠCP and PⅢNP (r = 0.688, P <0.01). Conclusions The content of ET-1, PⅠCP and PⅢNP in elderly patients with heart failure is increased, and endothelin is closely related to myocardial fibrosis.