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目的探讨氟康唑联合克霉唑治疗复发性念珠菌性外阴阴道炎的临床疗效。方法选取永新县妇幼保健院2013年1月—2015年1月收治的复发性念珠菌性外阴阴道炎200例,随机分为对照组和观察组,各100例。对照组给予氟康唑治疗,观察组给予氟康唑联合克霉唑治疗,两组患者均持续治疗3个月。观察比较两组患者的临床疗效、复发率及肝功能指标[天冬氨酸氨基转移酶(AST)、丙氨酸基转移酶(ALT)]。结果观察组患者临床疗效优于对照组,复发率低于对照组(P<0.05),观察组患者AST、ALT低于对照组(P<0.05)。结论氟康唑联合克霉唑治疗复发性念珠菌性外阴阴道炎临床疗效确切,可降低复发率,改善肝功能。
Objective To investigate the clinical efficacy of fluconazole combined with clotrimazole in the treatment of recurrent candidal vulvovaginitis. Methods 200 cases of recurrent candidal vulvovaginitis admitted to Yongxin County Maternal and Child Health Hospital from January 2013 to January 2015 were randomly divided into control group and observation group with 100 cases each. The control group was treated with fluconazole, the observation group was given fluconazole combined with clotrimazole treatment, both groups were treated for 3 months. The clinical efficacy, recurrence rate and liver function indicators (aspartate aminotransferase (AST), alanine trans-transferase (ALT)] of the two groups were observed and compared. Results The clinical efficacy of the observation group was better than that of the control group, and the recurrence rate was lower than that of the control group (P <0.05). The AST and ALT of the observation group were lower than those of the control group (P <0.05). Conclusion Fluconazole combined with clotrimazole is effective in treating recurrent candidal vulvovaginitis, which can reduce the recurrence rate and improve liver function.