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目的:评价莫匹罗星与纳米银凝胶联用对烧伤患者抗感染治疗的临床疗效。方法:选取2014年1月—2016年6月间收治的烧伤伴感染患者78例;采用随机综合平衡序贯法将其分为参照组参照组(n=39)和联合组(n=39);参照组患者给予单用莫匹罗星治疗,联合组患者在参照组的基础上加用纳米银凝胶治疗;评价两组患者治疗后的细菌清除率、创面愈合时间、住院时间及不良反应的发生率。结果:联合组患者用药后的细菌清除率高于参照组(P<0.05),创面愈合时间和住院时间均短于参照组(P<0.05);两组患者用药期均无不良反应发生。结论:在烧伤伴感染患者中采用莫匹罗星与纳米银凝胶联用治疗能够显著提高细菌清除率,促进创面愈合,缩短住院时间,安全性较为理想。
Objective: To evaluate the clinical efficacy of mupirocin combined with nanosilver gel in the treatment of burn patients. Methods: Seventy-eight patients with burn-related infection were selected from January 2014 to June 2016. The patients were divided into two groups according to the randomized combined balanced sequential therapy (n = 39) and the combination group (n = 39) ; The reference group was treated with mupirocin alone, and the combination group was treated with nano-silver gel on the basis of the reference group. The bacterial clearance rate, wound healing time, hospital stay and adverse reactions after treatment were evaluated in both groups The incidence of. Results: The bacterial clearance rate of the combined group was higher than that of the reference group (P <0.05), and the wound healing time and hospitalization time were shorter than the reference group (P <0.05). No adverse reactions occurred in the two groups. Conclusion: Mupirocin combined with nanosilver gel in patients with burn wound infection can significantly improve bacterial clearance rate, promote wound healing and shorten the hospital stay, and the safety is better.