【摘 要】
：
Background: This study aimed to assess the association between metabolic syndrome (MetS) and severity of nonalcoholic fatty liver disease (NAFLD), and to discuss the pathological relevance of the diagnostic criteria in metabolic (dysfunction) associated f
【机 构】
：
Center for Fatty Liver,Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiao To
论文部分内容阅读
Background: This study aimed to assess the association between metabolic syndrome (MetS) and severity of nonalcoholic fatty liver disease (NAFLD), and to discuss the pathological relevance of the diagnostic criteria in metabolic (dysfunction) associated fatty liver disease (MAFLD). Methods: This was a multicenter, cross-sectional study. Patients with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of China. Anthropometric and metabolic parameters were collected to assess the pathological relevance. Results: Of 246 enrolled patients with NAFLD, 150 (61.0％) had the comorbidity of MetS. With the increase of metabolic components, the proportions of nonalcoholic steatohepatitis (NASH) and significant fibrosis were notably increased. The comorbid three metabolic components significantly increased the proportion of NASH, and further increase of metabolic components did not increase the proportion of NASH. How- ever, the increase of metabolic components was parallel to the increase of the proportion of liver fibrosis. Among the 246 patients, 239 (97.2％) met the diagnostic criteria of MAFLD. Although non-MAFLD patients had less NASH, they present with similar proportion of significant fibrosis and cirrhosis. In the diagnostic criteria of MAFLD, BMI ≥ 23 kg/m 2 was related to NASH (Mantel-Haenszel Common Estimate OR: 2.975; 95％ CI: 1.037–8.538; P = 0.043), and T2DM was related to significant fibrosis (Mantel-Haenszel Com- mon Estimate OR: 2.531; 95％ CI: 1.388–4.613; P = 0.002). The homeostasis model assessment of insulin resistance (HOMA-IR) ≥ 2.5 was the most significant factor for NASH (OR: 4.100; 95％ CI: 1.772–9.487;P = 0.001) and significant factor for liver fibrosis (OR: 2.947; 95％ CI: 1.398–6.210; P = 0.004) after the adjustments of the BMI and diabetes. Conclusions: Metabolic dysregulations are important risk factors in NAFLD progression. The insulin resis- tance status may play a predominant role in the progression in MAFLD patients.
其他文献
To the Editor:rnOver the years, the shortage of suitable donor organs has chal- lenged the transplant community in performing life-saving liver transplantation (LT). Recent reports from European and American liver transplant registries show persistently h
To the Editor:rnIn the last decade, next-generation sequencing (NGS)-based molecular profiling has shed light on the molecular landscape of biliary tract cancer (BTC), revealing the presence of several poten- tially actionable mutations [1] . According to
To the Editor:rnHepatitis A and hepatitis E are acute infectious diseases caused by hepatitis A virus (HAV) and hepatitis E virus (HEV), which are mainly transmitted through the fecal-oral route [1] . The early clin- ical symptoms of patients with hepatit
Background: Endoscopic transpapillary gallbladder stenting (ETGBS) has been used as an alternative to percutaneous cholecystostomy in patients with acute cholecystitis who are considered unfit for surgery. However, there are few data on the efficacy and s
With the development of color Doppler and laparoscopic ultra- sound, now intraoperative ultrasound (IOUS) plays an important role in liver surgery. Compared to percutaneous ultrasound (US), IOUS is conducted directly on the liver surface, with no blind sp
Background: Nonalcoholic fatty liver disease (NAFLD) is a public health challenge and significant cause of morbidity and mortality worldwide. Early identification is crucial for disease intervention. We recently proposed a nomogram-based NAFLD prediction
Background: There are no clearly defined indications for pancreas-preserving duodenectomy. The present study aimed to analyze postoperative morbidity and the outcomes of patients undergoing pancreas- preserving duodenectomy. Methods: Patients undergoing p
Background: Liver injury is one of the most common complications during sepsis. Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine. This study explored the role of MIF in the lipopolysaccharide (LPS)-induced liver injury
Background: Although concomitant nonalcoholic steatohepatitis (NASH) is common in chronic hepatitis B (CHB), the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear. We aimed to investigate the outcomes of