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[目的]探讨甲真菌病患者的用药依从性及影响因素。[方法]回顾性分析本院皮肤科就诊的甲真菌病患者临床资料，分析患者用药依从性与性别、年龄、文化程度、职业等的相关性。[结果]434例患者按时按量服药者占21．7％（94/434），依从性差的占84．3％（340/434）；其中患者的性别、年龄、文化程度、职业、病程、治疗效果不佳、有不良反应、疗程长和忘记用药与患者依从性相关（ P ＜0．05），而患甲部位、知识掌握程度、不方便取药与患者依从性不相关（ P ＞0．05）；患者获取甲真菌病及相关药物知识主要来源于医务工作者347例（80．0％）。[结论]甲真菌病患者用药依从性差，因此医务工作者应根据具体情况对患者进行针对性教育，提高患者的用药依从性。“,”[Objective] To explore the medication compliance in patients with onychomycosis and its influ-ential factors .[Methods]Clinical data of patients with onychomycosis in dermatology department of our hospi-tal were analyzed retrospectively .The relationship of medication compliance with gender ,age ,education and occupation of patients were analyzed .[Results] The rate of good medication compliance was 15 .7% ,while that of bad medication compliance was 84 .3% .Medication compliance of patients was correlated with gender , age ,education ,occupation ,disease duration ,poor treatment effect ,adverse reactions ,long treatment course and oblivious medication( P 0 .05) .A total of 347 patients(80 .0% ) got the knowledge about onychomycosis and rel-evant drugs from medical workers .[Conclusion] Patients with onychomycosis have poor medication compli-ance ,so medical workers should try their best to educate the patients based on the specific circumstances in or-der to improve the medication compliance of patients .