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肿瘤抑制蛋白p16免疫组化染色是评价人乳头状瘤病毒(HPV)感染状态的主要依据,同时p16阳性也是提示HPV相关性口咽鳞状细胞癌预后良好的标志物。目前p16阳性重要的评价指标包括p16阳性细胞数及阳性融合细胞数,通常将>75%阳性细胞定义为p16阳性,而≤25%阳性细胞定义为p16阴性,另外将>50%阳性细胞且伴>25%融
Tumor suppressor protein p16 immunohistochemical staining is the main basis for evaluating the status of human papillomavirus (HPV) infection, and p16 positivity is also a good marker of HPV-related oropharyngeal squamous cell carcinoma prognosis. The most important p16-positive indicators include the number of positive p16 cells and the number of positive fusing cells. Usually,> 75% of positive cells are defined as positive for p16, while ≤25% of positive cells are defined as negative for p16. In addition,> 50% of positive cells are associated with > 25% financial