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目的探讨TGF-α基因TaqⅠ位点多态性与中国人群非综合征性唇腭裂的相关性。方法以非综合征性唇腭裂患者与对照组TGF-α基因TaqⅠ位点等位基因及基因型分布的OR值为效应指标,通过检索中国学术文献总库、维普、万方以及MEDLINE,PubMed,EMBASE等数据库中的相关文献,使用STATA10.0对各研究进行异质性检验和效应值合并,进行发表偏倚和敏感性分析。结果最终纳入11篇病例对照(病例亲本)研究,其中病例组1177例,对照组1293例。以等位基因C1以及基因型C1C1为参照,提示在TGF-α基因TaqⅠ位点中携带等位基因C2与非综合征性唇腭裂发病显著相关,携带C1C2或C2C2基因型的个体发生NSCL/P的风险增加(OR=2.00,95%CI:1.63～2.46)。结论在中国人群中,TGF-α基因TaqⅠ位点携带C1C2或C2C2基因型可能是非综合征性唇腭裂发病的危险因素。
Objective To investigate the association between TaqⅠ polymorphism of TGF-α gene and non-syndromic cleft lip and palate in Chinese population. Methods The OR of Taq Ⅰ allele and genotype distribution of TGF-α gene in patients with non-syndromic cleft lip and palate and control group was used as an index of effect. By searching the databases of Chinese academic literature, VIP, Wanfang and MEDLINE, PubMed, EMBASE and other related literature in the database, the use of STATA10.0 heterogeneity of each study test and the effect of merging, publication bias and sensitivity analysis. Results Finally, 11 case-control (case-parent) studies were included, of which 1177 were in the case group and 1293 in the control group. Using allele C1 and genotype C1C1 as a reference, it is suggested that there is a significant correlation between C2 carrying TaqⅠ gene in TGF-α gene and nonsyndromic cleft lip and palate. The individuals with C1C2 or C2C2 genotype had NSCL / P (OR = 2.00, 95% CI: 1.63 ~ 2.46). Conclusion In Chinese population, the TaqⅠ locus of TGF-α gene carrying C1C2 or C2C2 genotypes may be the risk factors of non-syndromic cleft lip and palate.