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A complex lead-zinc-silver sulfide ore containing 2.98% Pb,6.49% Zn and 116.32x10-4 % Ag (mass fraction) from Yunnan Province,China,was subjected to this work.Research on mineral processing was conducted according to the properties of the lead-zinc-silver ore.Under low alkalinity condition,the lead minerals are successfully separated from the zinc minerals with new reagent YZN as zinc depressant,new reagent BPB as lead collector,CuSO4 as zinc activator and ethyl xanthate as zinc collector.The associated silver is mostly concentrated to the lead concentrate.With the process utilized in this work,a lead concentrate of 51.90% Pb with a recovery of 82.34% and a zinc concentrate of 56.96% Zn with a recovery of 81.98% are produced.The silver recovery in the lead concentrate is 80.61%.Interactions of flotation reagents with minerals were investigated,of which the results indicate that the presence of proper amount of Na2S can precipitate Pb2+ and has a sulfidation on oxidized lead minerals.The results also show that Na2CO3 and YZN used together as combined depressants for sphalerite can signally improve the depressing effect of new reagent YZN on sphalerite.