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设计了一个直径为1 mm的新型植入式磁力驱动供药腔,该供药腔包括磁性薄膜、聚二甲基硅氧烷(PDMS)空腔、PDMS薄膜以及内径为0.4 mm的聚四氟乙烯(PTFE)导管构成,通过O2等离子处理工艺和键合形成空腔。将直流电源与铜线轴相连作为磁场源,通过其产生的磁场与磁性薄膜之间的磁力作用,磁性薄膜发生形变。当外部磁场开始工作时,通过改变电流大小控制药物供给量,磁性薄膜受到磁场的作用力对腔内的液体药物进行挤压,药物排出腔外。当外部磁场关闭后,磁性薄膜不再受到磁场的作用力,逐渐恢复原状,停止供药。经过测试,当磁感应强度达到100 mT时,供药系统的最大供药量为28.8μL。
A new implantable magnetically driven drug delivery cavity of 1 mm in diameter was designed. The drug delivery cavity consisted of a magnetic film, a PDMS cavity, a PDMS film, and a polytetrafluoroethylene Ethylene (PTFE) conduits, forming cavities by O2 plasma processing and bonding. The DC power supply is connected with the copper shaft as a magnetic field source, and the magnetic film is deformed by the magnetic force generated between the magnetic field and the magnetic film. When the external magnetic field begins to work, by changing the current size control the amount of drug supply, the magnetic film by the force of the magnetic field on the cavity of the liquid drug extrusion, drug out of the cavity. When the external magnetic field is turned off, the magnetic film is no longer subject to the force of the magnetic field, gradually restored to its original state, to stop the drug. After testing, when the magnetic flux density reaches 100 mT, the maximum dosage for the drug delivery system is 28.8 μL.