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别嘌醇是黄嘌呤氧化酶抑制剂,通过阻止次黄嘌呤转化为黄嘌呤来减少尿酸合成,临床广泛用于痛风和高尿酸血症的治疗。随着别嘌醇临床应用日益广泛,其引起药物不良反应的报道也逐渐增多,以皮疹最为常见,其发生率高达10%[1],轻者临床表现为麻疹样皮疹或红色斑丘疹,较为严重者则可能出现重症渗出多形性红斑(stevens-johnson syndrome,SJS)、中毒性表皮坏死松懈症(toxic epidermal necrolysis,TEN)。当患者服用别嘌醇后出现以上严重SJS或TEN皮肤不良反应,同时合并明显的血液、肝、肾多器官受
Allopurinol is a xanthine oxidase inhibitor that reduces uric acid synthesis by preventing the conversion of hypoxanthine to xanthine and is widely used in the treatment of gout and hyperuricemia. With the increasing clinical application of allopurinol, the reports of adverse drug reactions are gradually increasing, the rash is the most common, the incidence rate is as high as 10% [1], the clinical manifestation of the mild is measles-like rash or red rash, more In severe cases, severe exudative stevens-johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) may occur. When patients taking allopurinol after the above serious side effects of SJS or TEN skin, combined with significant blood, liver and kidney multiple organ receptor