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目的探讨脓毒症患者的病情预后与高密度脂蛋白(HDL)之间的关联性。方法 2008年3月1日-2010年2月28日选择50例严重脓毒症患者(脓毒症组)和30例非脓毒症的健康人(对照组),比较两组急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)和HDL水平。结果脓毒症组的HDL水平为(1.10±0.39)mmol/L,对照组HDL水平为(1.61±0.42)mmol/L,两组差异有统计学意义(t=6.786,P=0.000)。多因素非条件logistic回归分析显示,HDL水平(OR=0.877,P=0.025)和APACHEⅡ评分(OR=15.556,P=0.009)是影响脓毒症患者患病程度的两个有效独立因素。结论脓毒症能够导致患者的脂代谢出现紊乱,HDL水平是评估脓毒症患病程度的较好指标。
Objective To investigate the relationship between the prognosis of patients with sepsis and high density lipoprotein (HDL). Methods From March 1, 2008 to February 28, 2010, 50 patients with severe sepsis (sepsis) and 30 healthy people without sepsis (control group) were selected. The acute physiology and chronic Health status score Ⅱ (APACHE Ⅱ) and HDL levels. Results The level of HDL in sepsis group was (1.10 ± 0.39) mmol / L, while the level of HDL in control group was (1.61 ± 0.42) mmol / L. There was significant difference between the two groups (t = 6.786, P = 0.000). Multivariate non-conditional logistic regression analysis showed that HDL levels (OR = 0.877, P = 0.025) and APACHEⅡscore (OR = 15.556, P = 0.009) were two effective independent factors affecting the severity of sepsis. Conclusions Sepsis can lead to disorder of lipid metabolism in patients. HDL level is a good indicator to evaluate the severity of sepsis.