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目的:探讨肺间质纤维化患者应用自拟中药汤剂联合西药治疗临床疗效分析及其安全性评价,为临床诊断治疗提供参考。方法:将纳入98例肺间质纤维化患者根据随机数字表法随机分为对照组(n=49)和观察组(n=49);对照组给予西药治疗,观察组在西药治疗基础上结合自拟中药汤剂治疗;两组患者均以4周为1个疗程,2个疗程后评价其疗效及安全性。结果:观察组治疗后总有效率(89.80%)显著高于对照组(71.43%),且有显著性差异(P<0.05);观察组治疗后弥散功能和动脉氧分压显著高于治疗前,且有显著性差异(P<0.05);观察组治疗后FVC和FEV1明显高于治疗前及对照组治疗后,且差异具有统计学意义(P<0.05);两组患者治疗过程中均未出现明显的不良反应。结论:肺间质纤维化患者应用自拟中药汤剂联合西药治疗临床疗效显著,安全可靠,临床应用具有重要意义,值得进一步推广应用。
Objective: To investigate the clinical efficacy of self-made Chinese medicine decoction combined with Western medicine in patients with pulmonary fibrosis and its safety evaluation, so as to provide reference for clinical diagnosis and treatment. Methods: Ninety-eight patients with pulmonary interstitial fibrosis were randomly divided into control group (n = 49) and observation group (n = 49) according to random number table. The control group received western medicine treatment. The observation group was combined with western medicine treatment Self-made Chinese medicine decoction treatment; two groups of patients were 4 weeks for a course of treatment, 2 after treatment to evaluate its efficacy and safety. Results: The total effective rate (89.80%) in the observation group was significantly higher than that in the control group (71.43%), and there was significant difference (P <0.05). The diffuse function and arterial oxygen tension in observation group were significantly higher than those before treatment (P <0.05). The FVC and FEV1 in the observation group were significantly higher than those before treatment and in the control group after treatment (P <0.05), and no difference was found between the two groups in the course of treatment Significant adverse reactions. Conclusion: The clinical efficacy of self-made traditional Chinese medicine decoction combined with western medicine in patients with pulmonary fibrosis is significant, safe and reliable, and clinical application is of great significance and worth further promotion and application.