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目的分析应用小剂量阿司匹林肠溶片改善高危妊娠期高血压疾病(HDCP)患者凝血功能的临床效果。方法选择2013年10月-2014年10月高危HDCP患者128例,随机分成对照组64例和观察组64例,对照组患者给予安慰剂,观察组应用小剂量阿司匹林肠溶片,两组患者治疗后,观察患者的凝血功能的变化情况,并将两组治疗效果进行对比。结果观察组在治疗后凝血功能有显著性的改善,凝血酶原时间(PT)、凝血酶时间(TT)明显延长,血浆纤维蛋白原(Fib)值降低,D-二聚体值增高,观察组的凝血功能明显优于对照组(P<0.05)。观察组并发症的发病率为15.63%,对照组的并发症发病率为34.38%,两者存在统计学差异(P<0.05)。结论小剂量阿司匹林肠溶片可以改善高危HDCP患者的凝血功能,临床效果好,可降低妊高征并发症的发生率。
Objective To analyze the clinical effect of using low-dose aspirin enteric-coated tablets to improve coagulation function in patients with high-risk gestational hypertension (HDCP). Methods A total of 128 high-risk HDCP patients from October 2013 to October 2014 were randomly divided into control group (64 cases) and observation group (64 cases). Patients in the control group were given placebo. Patients in the observation group received low-dose aspirin enteric- After the observation of changes in the patient’s coagulation function, and the two groups compared the therapeutic effect. Results After treatment, the coagulation function of the observation group was significantly improved. Prothrombin time (PT) and thrombin time (TT) were significantly prolonged, plasma fibrinogen (Fib) value was decreased and D-dimer value was increased. The coagulation function of the group was significantly better than that of the control group (P <0.05). The incidence of complications in the observation group was 15.63%, while the incidence of complications in the control group was 34.38%, there was a statistically significant difference (P <0.05). Conclusion Small-dose aspirin enteric-coated tablets can improve the coagulation function of high-risk HDCP patients with good clinical effect and reduce the incidence of complications of pregnancy-induced hypertension.