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各种淋巴细胞之间的功能区别常在细胞膜表面特性上表现出来。因此,分析膜表面标记是鉴别和计数不同淋巴细胞群的一种很好的方法。人类B淋巴细胞(B细胞)具有表面Ig,而在人类T淋巴细胞上则不能测出表面Ig,人的T细胞能在0℃与羊红细胞结合。后来发展为用小鼠同种异体抗血清区别辅助T细胞(Lyl~+)和抑制T细胞(Ly23~+),这些导致最终发现了人类T细胞异种抗原(TH1),这种TH1抗原的性质同小鼠的Ly1相似,仅限于辅助T细胞上。除了TH1抗原标记外,有人报导人的辅助和抑制T细胞可因其不同Fc受体类型而加以区别,分离的带有IgG-Fc受体(FcγR))的人T细胞具有抑制T细胞活力,带有IgM-Fc受体(FcuR)的T细胞具有辅助T细胞活力。可见,各个类型的淋巴细胞功能都与其膜表面特性有关。
Functional differences between various lymphocytes often appear on the surface properties of the cell membrane. Therefore, analysis of membrane surface markers is a good way to identify and count different lymphocyte populations. Human B lymphocytes (B cells) have surface Ig, while human IgCs do not detect surface Ig. Human T cells can bind to sheep erythrocytes at 0 ° C. Later developed to differentiate between helper T cells (Lyl ~ +) and suppress T cells (Ly23 +) using mouse alloantibodies, which led to the discovery of the human T cell heterologous antigen (TH1), the nature of this TH1 antigen Similar to mouse Ly1, restricted to helper T cells. In addition to the TH1 antigen marker, it has been reported that human T helper and suppress T cells can be distinguished by their different Fc receptor types, isolated human T cells with IgG-Fc receptor (FcγR)) have the ability to inhibit T cell viability, T cells with IgM-Fc receptor (FcuR) have helper T cell viability. Can be seen that all types of lymphocyte function with its membrane surface properties.