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目的 通过检测系统性红斑狼疮 (SLE)患者血清白细胞介素 4(IL 4)、γ 干扰素(IFN γ)的水平 ,探讨T淋巴细胞亚群与SLE发病的关系。方法 采用酶联免疫吸附法测定SLE患者和健康志愿者血清IL 4和IFN γ水平。结果 (1)SLE活动组血清IL 4水平和IL 4/IFN γ比值明显升高 ,与非活动组和对照组比较 ,差异有非常显著性 (P <0 .0 0 1) ;(2 )血清IFN γ水平三组 (SLE活动组、非活动组和对照组 )比较 ,差异无显著性 (P >0 .0 5 ) ;(3 )SLE患者激素治疗后血清IL 4水平明显降低。结论 SLE患者血清IL 4水平和IL 4/IFN γ比值明显升高 ,且与病情活动性相关 ,IFN γ水平无明显变化 ,活动性SLE患者存在Th2细胞优势活化状态 ,破坏了体内Th1/Th2正常平衡
Objective To explore the relationship between T lymphocyte subsets and the pathogenesis of SLE by detecting the levels of serum interleukin 4 (IL 4) and interferon gamma (IFN γ) in patients with systemic lupus erythematosus (SLE). Methods Serum levels of IL 4 and IFN γ were measured by enzyme-linked immunosorbent assay in patients with SLE and healthy volunteers. Results (1) The levels of IL 4 and IL 4 / IFN γ in SLE group were significantly higher than those in inactive group and control group (P <0.01). (2) Serum (P> 0.05). (3) The level of IL-4 in serum of patients with SLE was significantly lower than that of the control group (P <0.05). Conclusion The serum levels of IL 4 and IL 4 / IFN γ in patients with SLE are significantly higher than those in patients with SLE, and are associated with the activity of the disease. There is no significant change in the level of IFN γ. The patients with active SLE have the predominant activation state of Th2 cells and disrupt the normal Th1 / Th2 in vivo balance