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目的研究糖皮质激素联合复方异丙托溴铵对慢性阻塞性肺疾病(慢阻肺)急性加重期的治疗意义。方法 100例慢阻肺患者,根据信封随机分组法分为A组和B组,各50例。A组在常规抗感染治疗的同时给予糖皮质激素;B组在A组基础上联合复方异丙托溴铵。比较两组用药前后患者最大呼气流速(PEF)、氧分压(PO_2)、二氧化碳分压(PCO_2)以及第1秒用力呼气容积占有力肺活量百分比(FEV1/FVC)的差异,并比较治疗效果。结果治疗后,B组治疗总有效率为96.00%,显著高于A组的78.00%(P<0.05);用药后B组PEF、PO_2、PCO_2以及FEV1/FVC改善幅度更大,优于A组(P<0.05)。结论糖皮质激素联合复方异丙托溴铵对慢阻肺急性加重期的治疗效果确切,可有效改善患者临床症状和血气分析指标,预防病情进展,值得推广。
Objective To study the therapeutic effect of glucocorticoids combined with ipratropium bromide on acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods One hundred patients with chronic obstructive pulmonary disease (COPD) were divided into group A and group B according to the envelope randomization method, 50 cases in each group. Group A was treated with conventional anti-infective therapy with glucocorticoid; Group B was combined with ipratropium bromide on the basis of group A. The differences of maximum expiratory flow (PEF), partial pressure of oxygen (PO_2), partial pressure of carbon dioxide (PCO_2) and FEV 1 / FVC between the two groups before and after treatment were compared. effect. Results After treatment, the total effective rate in group B was 96.00%, which was significantly higher than that in group A (78.00%, P <0.05). After treatment, PEF, PO_2, PCO_2 and FEV1 / FVC in group B improved more obviously than group A (P <0.05). Conclusion Glucocorticoid combined with ipratropium bromide is effective in the treatment of acute exacerbation of chronic obstructive pulmonary disease, which can effectively improve the clinical symptoms and blood gas analysis indexes of patients and prevent the progression of the disease, which is worthy of popularization.